Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats
المؤلفون المشاركون
Jiang, Mao
Melling, C. W. James
McDonald, Matthew W.
Dotzert, Michelle S.
Murray, Michael R.
Noble, Earl G.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Intensive insulin therapy (IIT; 4–7 mmol/L) is the preferred treatment for type 1 diabetes mellitus (T1DM) patients to reduce the risk of cardiovascular disease (CVD).
However, this treatment strategy has been questioned as it is accompanied with a sedentary lifestyle leading to weight gain and insulin resistance.
T1DM patients who partake in high-intensity aerobic training (AThigh) to reduce CVD often utilize conventional insulin therapy (CIT; 9–15 mmol/L) to offset the risk of hypoglycemia.
Moreover, exercise modalities incorporating resistance training (RT) have been shown to further reduce this risk.
The purpose of this investigation was twofold: (1) to determine if CIT paired with AThigh results in larger cardioprotection from an ischemia-reperfusion (I-R) injury than IIT and (2) to establish if the integration of RT with AThigh (ART) results in similar cardioprotection as AThigh.
Diabetic (D) male Sprague-Dawley rats were divided into D-IIT (n=12), D-CIT (n=12), D-AThigh (n=8), D-RT (n=8), and D-ART (n=8).
T1DM was induced with streptozotocin, and blood glucose was adjusted with insulin.
D-AThigh occurred on a treadmill (27 m/min; 1 hr), D-RT performed weighted ladder climbs, and D-ART alternated daily between AThigh and RT.
Exercise occurred 5 days/wk for 12 wks.
This investigation demonstrates that cardioprotection following an I-R injury was similar between D-AThigh and D-IIT.
This cardioprotection is not exercise-specific, and each provides unique advantages.
D-AThigh leads to improved glycemia while insulin sensitivity was enhanced following resistance exercises.
Thus, exercise is an effective means to elicit cardioprotection in T1DM.
However, in addition to glycemia, other factors should be considered when tailoring an exercise program for T1DM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McDonald, Matthew W.& Dotzert, Michelle S.& Jiang, Mao& Murray, Michael R.& Noble, Earl G.& Melling, C. W. James. 2018. Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183968
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McDonald, Matthew W.…[et al.]. Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats. Journal of Diabetes Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1183968
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McDonald, Matthew W.& Dotzert, Michelle S.& Jiang, Mao& Murray, Michael R.& Noble, Earl G.& Melling, C. W. James. Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183968
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183968
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر