Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer
المؤلفون المشاركون
Aryal, Bibek
Yamakuchi, Munekazu
Shimizu, Toshiaki
Kadono, Jun
Furoi, Akira
Gejima, Kentaro
Komokata, Teruo
Hashiguchi, Teruto
Imoto, Yutaka
Koriyama, Chihaya
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
Platelet derived growth factor-BB (PDGF-BB) has emerged as one of the key cytokines in malignant transformation of different cells.
PDGF-BB also exhibits a potent mitogenic effect on liver cells; studies have advocated clinical implications of monitoring serum PDGF-BB (sPDGF-BB) in patients with liver disease.
We thus investigated the predictive relevance of perioperative sPDGF-BB after curative resection of hepatocellular carcinoma (HCC).
Methods.
We evaluated perioperative sPDGF-BB in a prospective homogenous cohort of 40 patients diagnosed with HCC.
During the first two-year follow-up, patients were evaluated every three months for postresection HCC recurrence.
Results.
Patients who developed recurrence during two-year follow-up were found to have lower concentration of sPDGF-BB than those without recurrence in both pre- and postoperative settings (P < 0.05 and P < 0.001, resp.).
We validated that the reduced postoperative sPDGF-BB (< 2133.29 pg/mL) was associated with an increased incidence of postresection HCC recurrence [area under curve (AUC) > 0.8, 95% confidence interval (CI) = 0.68 - 0.94, P < 0.001]; furthermore, we were able to demonstrate that postoperative sPDGF-BB was an independent predictor of HCC recurrence (hazard ratio = 5.64, 95% CI = 1.56 - 20.30, P < 0.01).
Conclusions.
These findings provide a new insight into an association between diminished perioperative sPDGF-BB and HCC recurrence.
Patients with low perioperative sPDGF-BB progressed early HCC recurrence.
Therefore, evaluating perioperative sPDGF-BB may provide useful clinical information to characterize patients with postresection HCC recurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aryal, Bibek& Yamakuchi, Munekazu& Shimizu, Toshiaki& Kadono, Jun& Furoi, Akira& Gejima, Kentaro…[et al.]. 2019. Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183989
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aryal, Bibek…[et al.]. Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1183989
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aryal, Bibek& Yamakuchi, Munekazu& Shimizu, Toshiaki& Kadono, Jun& Furoi, Akira& Gejima, Kentaro…[et al.]. Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183989
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183989
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر