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Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer
Joint Authors
Aryal, Bibek
Yamakuchi, Munekazu
Shimizu, Toshiaki
Kadono, Jun
Furoi, Akira
Gejima, Kentaro
Komokata, Teruo
Hashiguchi, Teruto
Imoto, Yutaka
Koriyama, Chihaya
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Platelet derived growth factor-BB (PDGF-BB) has emerged as one of the key cytokines in malignant transformation of different cells.
PDGF-BB also exhibits a potent mitogenic effect on liver cells; studies have advocated clinical implications of monitoring serum PDGF-BB (sPDGF-BB) in patients with liver disease.
We thus investigated the predictive relevance of perioperative sPDGF-BB after curative resection of hepatocellular carcinoma (HCC).
Methods.
We evaluated perioperative sPDGF-BB in a prospective homogenous cohort of 40 patients diagnosed with HCC.
During the first two-year follow-up, patients were evaluated every three months for postresection HCC recurrence.
Results.
Patients who developed recurrence during two-year follow-up were found to have lower concentration of sPDGF-BB than those without recurrence in both pre- and postoperative settings (P < 0.05 and P < 0.001, resp.).
We validated that the reduced postoperative sPDGF-BB (< 2133.29 pg/mL) was associated with an increased incidence of postresection HCC recurrence [area under curve (AUC) > 0.8, 95% confidence interval (CI) = 0.68 - 0.94, P < 0.001]; furthermore, we were able to demonstrate that postoperative sPDGF-BB was an independent predictor of HCC recurrence (hazard ratio = 5.64, 95% CI = 1.56 - 20.30, P < 0.01).
Conclusions.
These findings provide a new insight into an association between diminished perioperative sPDGF-BB and HCC recurrence.
Patients with low perioperative sPDGF-BB progressed early HCC recurrence.
Therefore, evaluating perioperative sPDGF-BB may provide useful clinical information to characterize patients with postresection HCC recurrence.
American Psychological Association (APA)
Aryal, Bibek& Yamakuchi, Munekazu& Shimizu, Toshiaki& Kadono, Jun& Furoi, Akira& Gejima, Kentaro…[et al.]. 2019. Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183989
Modern Language Association (MLA)
Aryal, Bibek…[et al.]. Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1183989
American Medical Association (AMA)
Aryal, Bibek& Yamakuchi, Munekazu& Shimizu, Toshiaki& Kadono, Jun& Furoi, Akira& Gejima, Kentaro…[et al.]. Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183989