Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes
المؤلفون المشاركون
Chisalita, Simona I.
Ludvigsson, Johnny
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein.
Objective.
To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D.
Methods.
Ten girls and ten boys with type 1 diabetes (T1D), aged 13.0 ± 1.4 (mean ± SD) years at diagnosis, took part in the study.
Blood samples were drawn at diagnosis and after 3, 9, 18, and 48 months.
HbA1c, total IGF-1, and C-peptide were measured.
Results.
At diagnosis, the patients had high HbA1c, low IGF-1, and measurable C-peptide.
After the start of insulin treatment, maximal improvement in glycemic control and IGF-1 occurred within 3 months and then both tended to deteriorate, that is, HbA1c to increase and IGF-1 to decrease.
C-peptide decreased with time, and after 4 years, half of the patients were C-peptide negative.
At diagnosis, C-peptide correlated positively to IGF-1 (r=0.50; p<0.03).
C-peptide correlated negatively with insulin dose (U/kg) after 18 and 48 months from diagnosis (r=−0.48; p<0.03 and r=−0.72; p<0.001, resp.).
Conclusions.
In conclusion, our results show that in newly diagnosed adolescents with type 1 diabetes and deranged metabolism, the IGF-1 level is low and rapidly improves with insulin treatment but later tends to decrease concomitantly with declining endogenous insulin secretion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chisalita, Simona I.& Ludvigsson, Johnny. 2018. Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chisalita, Simona I.& Ludvigsson, Johnny. Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes. Journal of Diabetes Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1183990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chisalita, Simona I.& Ludvigsson, Johnny. Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر