Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes
Joint Authors
Chisalita, Simona I.
Ludvigsson, Johnny
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein.
Objective.
To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D.
Methods.
Ten girls and ten boys with type 1 diabetes (T1D), aged 13.0 ± 1.4 (mean ± SD) years at diagnosis, took part in the study.
Blood samples were drawn at diagnosis and after 3, 9, 18, and 48 months.
HbA1c, total IGF-1, and C-peptide were measured.
Results.
At diagnosis, the patients had high HbA1c, low IGF-1, and measurable C-peptide.
After the start of insulin treatment, maximal improvement in glycemic control and IGF-1 occurred within 3 months and then both tended to deteriorate, that is, HbA1c to increase and IGF-1 to decrease.
C-peptide decreased with time, and after 4 years, half of the patients were C-peptide negative.
At diagnosis, C-peptide correlated positively to IGF-1 (r=0.50; p<0.03).
C-peptide correlated negatively with insulin dose (U/kg) after 18 and 48 months from diagnosis (r=−0.48; p<0.03 and r=−0.72; p<0.001, resp.).
Conclusions.
In conclusion, our results show that in newly diagnosed adolescents with type 1 diabetes and deranged metabolism, the IGF-1 level is low and rapidly improves with insulin treatment but later tends to decrease concomitantly with declining endogenous insulin secretion.
American Psychological Association (APA)
Chisalita, Simona I.& Ludvigsson, Johnny. 2018. Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183990
Modern Language Association (MLA)
Chisalita, Simona I.& Ludvigsson, Johnny. Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes. Journal of Diabetes Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1183990
American Medical Association (AMA)
Chisalita, Simona I.& Ludvigsson, Johnny. Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183990