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ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases
المؤلفون المشاركون
Ganea, Constanta
Mocanu, Maria Magdalena
Filippi, Alexandru
Ciolac, Oana-Alina
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-13
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
ErbB proteins overexpression, in both normal and mutated forms, is associated with invasive forms of cancer prone to metastasis and with stronger antiapoptotic mechanisms and therefore more challenging to treat.
Downstream effectors of ErbB receptors mediating these phenotypic traits include MAPK, STAT, and PI3K/AKT/mTOR pathways.
Various phytochemical compounds were studied for their large number of biological effects including anticancer activity.
Among these compounds, epigallocatechin-3-gallate (EGCG), the main catechin from green tea leaves, and curcumin, component of the curry powder, constituted the object of numerous studies.
Both compounds were shown to act directly either on ErbB expression, or on their downstream signaling molecules.
In this paper we aim to review the involvement of ErbB proteins in cancer as well as the biologic activity of EGCG and curcumin in ErbB expressing and overexpressing malignancies.
The problems arising in the administration of the two compounds due to their reduced bioavailability when orally administered, as well as the progress made in this field, from using novel formulations to improved dosing regimens or improved synthetic analogs, are also discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Filippi, Alexandru& Ciolac, Oana-Alina& Ganea, Constanta& Mocanu, Maria Magdalena. 2017. ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases. Journal of Oncology،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1184173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Filippi, Alexandru…[et al.]. ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases. Journal of Oncology No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1184173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Filippi, Alexandru& Ciolac, Oana-Alina& Ganea, Constanta& Mocanu, Maria Magdalena. ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases. Journal of Oncology. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1184173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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