ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases
Joint Authors
Ganea, Constanta
Mocanu, Maria Magdalena
Filippi, Alexandru
Ciolac, Oana-Alina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
ErbB proteins overexpression, in both normal and mutated forms, is associated with invasive forms of cancer prone to metastasis and with stronger antiapoptotic mechanisms and therefore more challenging to treat.
Downstream effectors of ErbB receptors mediating these phenotypic traits include MAPK, STAT, and PI3K/AKT/mTOR pathways.
Various phytochemical compounds were studied for their large number of biological effects including anticancer activity.
Among these compounds, epigallocatechin-3-gallate (EGCG), the main catechin from green tea leaves, and curcumin, component of the curry powder, constituted the object of numerous studies.
Both compounds were shown to act directly either on ErbB expression, or on their downstream signaling molecules.
In this paper we aim to review the involvement of ErbB proteins in cancer as well as the biologic activity of EGCG and curcumin in ErbB expressing and overexpressing malignancies.
The problems arising in the administration of the two compounds due to their reduced bioavailability when orally administered, as well as the progress made in this field, from using novel formulations to improved dosing regimens or improved synthetic analogs, are also discussed.
American Psychological Association (APA)
Filippi, Alexandru& Ciolac, Oana-Alina& Ganea, Constanta& Mocanu, Maria Magdalena. 2017. ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases. Journal of Oncology،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1184173
Modern Language Association (MLA)
Filippi, Alexandru…[et al.]. ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases. Journal of Oncology No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1184173
American Medical Association (AMA)
Filippi, Alexandru& Ciolac, Oana-Alina& Ganea, Constanta& Mocanu, Maria Magdalena. ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases. Journal of Oncology. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1184173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184173