Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding
المؤلفون المشاركون
Sacchetti, Lucia
Nardelli, Carmela
Ferrigno, Maddalena
Buono, Pasqualina
Dodaro, Concetta
Carlomagno, Nicola
Pilone, Vincenzo
Iaffaldano, Laura
Forestieri, Pietro
Salvatore, Francesco
Labruna, Giuseppe
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Laparoscopic adjustable gastric banding (LAGB) results in significant lasting weight loss and improved metabolism in obese patients.
To evaluate whether epigenetic factors could concur to these benefits, we investigated the subcutaneous adipose tissue (SAT) microRNA (miRNA) profile before (T0) and three years (T1) after LAGB in three morbidly obese women.
Case Reports.
SAT miRNA profiling, evaluated by TaqMan Array, showed four downexpressed (miR-519d, miR-299-5p, miR-212, and miR-671-3p) and two upexpressed (miR-370 and miR-487a) miRNAs at T1 versus T0.
Bioinformatics predicted that these miRNAs regulate genes belonging to pathways associated with the cytoskeleton, inflammation, and metabolism.
Western blot analysis showed that PPAR-alpha, which is the target gene of miR-519d, increased after LAGB, thereby suggesting an improvement in SAT lipid metabolism.
Accordingly, the number and diameter of adipocytes were significantly higher and lower, respectively, at T1 versus T0.
Bioinformatics predicted that the decreased levels of miR-212, miR-299-5p, and miR-671-3p at T1 concur in reducing SAT inflammation.
Conclusion.
We show that the miRNA profile changes after LAGB.
This finding, although obtained in only three cases, suggests that this epigenetic mechanism, by regulating the expression of genes involved in inflammation and lipid metabolism, could concur to improve SAT functionality in postoperative obese patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nardelli, Carmela& Iaffaldano, Laura& Pilone, Vincenzo& Labruna, Giuseppe& Ferrigno, Maddalena& Carlomagno, Nicola…[et al.]. 2017. Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding. Journal of Obesity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184318
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nardelli, Carmela…[et al.]. Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding. Journal of Obesity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1184318
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nardelli, Carmela& Iaffaldano, Laura& Pilone, Vincenzo& Labruna, Giuseppe& Ferrigno, Maddalena& Carlomagno, Nicola…[et al.]. Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding. Journal of Obesity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184318
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184318
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر