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Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease
المؤلفون المشاركون
Hamrah, Pedram
Cheng, Anny M. S.
John, Thomas
Tighe, Sean
Sheha, Hosam
Salem, Zeina M.
Wang, Ming X.
Rock, Nathan D.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED).
Methods.
In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control).
Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months.
Results.
Twenty subjects (age 66.9 ± 8.9) were enrolled and 17 completed all follow-up visits.
Signs and symptoms were significantly improved in the study group yet remained constant in the control.
IVCM showed a significant increase in corneal nerve density in the study group (12,241 ± 5083 μm/mm2 at baseline, 16,364 ± 3734 μm/mm2 at 1 month, and 18,827 ± 5453 μm/mm2 at 3 months, p=0.015) but was unchanged in the control.
This improvement was accompanied with a significant increase in corneal sensitivity (3.25 ± 0.6 cm at baseline, 5.2 ± 0.5 cm at 1 month, and 5.6 ± 0.4 cm at 3 months, p<0.001) and corneal topography only in the study group.
Conclusions.
Self-retained CAM is a promising therapy for corneal nerve regeneration and accelerated recovery of the ocular surface health in patients with DED.
The study is registered at clinicaltrials.gov with trial identifier: NCT02764814.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
John, Thomas& Tighe, Sean& Sheha, Hosam& Hamrah, Pedram& Salem, Zeina M.& Cheng, Anny M. S.…[et al.]. 2017. Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1185155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
John, Thomas…[et al.]. Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease. Journal of Ophthalmology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1185155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
John, Thomas& Tighe, Sean& Sheha, Hosam& Hamrah, Pedram& Salem, Zeina M.& Cheng, Anny M. S.…[et al.]. Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1185155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1185155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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