Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease
Joint Authors
Hamrah, Pedram
Cheng, Anny M. S.
John, Thomas
Tighe, Sean
Sheha, Hosam
Salem, Zeina M.
Wang, Ming X.
Rock, Nathan D.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED).
Methods.
In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control).
Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months.
Results.
Twenty subjects (age 66.9 ± 8.9) were enrolled and 17 completed all follow-up visits.
Signs and symptoms were significantly improved in the study group yet remained constant in the control.
IVCM showed a significant increase in corneal nerve density in the study group (12,241 ± 5083 μm/mm2 at baseline, 16,364 ± 3734 μm/mm2 at 1 month, and 18,827 ± 5453 μm/mm2 at 3 months, p=0.015) but was unchanged in the control.
This improvement was accompanied with a significant increase in corneal sensitivity (3.25 ± 0.6 cm at baseline, 5.2 ± 0.5 cm at 1 month, and 5.6 ± 0.4 cm at 3 months, p<0.001) and corneal topography only in the study group.
Conclusions.
Self-retained CAM is a promising therapy for corneal nerve regeneration and accelerated recovery of the ocular surface health in patients with DED.
The study is registered at clinicaltrials.gov with trial identifier: NCT02764814.
American Psychological Association (APA)
John, Thomas& Tighe, Sean& Sheha, Hosam& Hamrah, Pedram& Salem, Zeina M.& Cheng, Anny M. S.…[et al.]. 2017. Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1185155
Modern Language Association (MLA)
John, Thomas…[et al.]. Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease. Journal of Ophthalmology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1185155
American Medical Association (AMA)
John, Thomas& Tighe, Sean& Sheha, Hosam& Hamrah, Pedram& Salem, Zeina M.& Cheng, Anny M. S.…[et al.]. Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1185155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185155