In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice
المؤلفون المشاركون
Gashe Fufa, Fanta
Mulisa Bobasa, Eshetu
Zeleke, Gemechu
Kebebe, Dereje
المصدر
Journal of Parasitology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Currently, antimalarial drug resistance poses a serious challenge.
This stresses the need for newer antimalarial compounds.
Carica papaya is used traditionally and showed in vitro antimalarial activity.
This study attempted to evaluate in vivo antimalarial activity of C.
papaya in mice.
Methods.
In vivo antimalarial activity of solvent fractions of the plant was carried out against early P.
berghei infection in mice.
Parasitemia, temperature, PCV, and body weight of mice were recorded.
Windows SPSS version 16 (one-way ANOVA followed by Tukey’s post hoc test) was used for data analysis.
Results.
The pet ether and chloroform fractions of C.
papaya fruit rind and root produced a significant (p<0.001) chemosuppressive effect.
A maximum parasite suppression of 61.78% was produced by pet ether fraction of C.
papaya fruit rind in the highest dose (400 mg/kg/day).
Only 400 mg/kg/day dose of chloroform fraction of C.
papaya root exhibited a parasite suppression effect (48.11%).
But, methanol fraction of the plant parts produced less chemosuppressive effect.
Conclusion.
Pet ether fraction of C.
papaya fruit rind had the highest antimalarial activity and could be a potential source of lead compound.
Further study should be done to show the chemical and metabolomic profile of active ingredients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeleke, Gemechu& Kebebe, Dereje& Mulisa Bobasa, Eshetu& Gashe Fufa, Fanta. 2017. In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice. Journal of Parasitology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1186198
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeleke, Gemechu…[et al.]. In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice. Journal of Parasitology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1186198
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeleke, Gemechu& Kebebe, Dereje& Mulisa Bobasa, Eshetu& Gashe Fufa, Fanta. In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice. Journal of Parasitology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1186198
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1186198
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر