In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae)‎ against Plasmodium berghei in Mice

Joint Authors

Gashe Fufa, Fanta
Mulisa Bobasa, Eshetu
Zeleke, Gemechu
Kebebe, Dereje

Source

Journal of Parasitology Research

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-12-17

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Zoology
Diseases

Abstract EN

Background.

Currently, antimalarial drug resistance poses a serious challenge.

This stresses the need for newer antimalarial compounds.

Carica papaya is used traditionally and showed in vitro antimalarial activity.

This study attempted to evaluate in vivo antimalarial activity of C.

papaya in mice.

Methods.

In vivo antimalarial activity of solvent fractions of the plant was carried out against early P.

berghei infection in mice.

Parasitemia, temperature, PCV, and body weight of mice were recorded.

Windows SPSS version 16 (one-way ANOVA followed by Tukey’s post hoc test) was used for data analysis.

Results.

The pet ether and chloroform fractions of C.

papaya fruit rind and root produced a significant (p<0.001) chemosuppressive effect.

A maximum parasite suppression of 61.78% was produced by pet ether fraction of C.

papaya fruit rind in the highest dose (400 mg/kg/day).

Only 400 mg/kg/day dose of chloroform fraction of C.

papaya root exhibited a parasite suppression effect (48.11%).

But, methanol fraction of the plant parts produced less chemosuppressive effect.

Conclusion.

Pet ether fraction of C.

papaya fruit rind had the highest antimalarial activity and could be a potential source of lead compound.

Further study should be done to show the chemical and metabolomic profile of active ingredients.

American Psychological Association (APA)

Zeleke, Gemechu& Kebebe, Dereje& Mulisa Bobasa, Eshetu& Gashe Fufa, Fanta. 2017. In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice. Journal of Parasitology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1186198

Modern Language Association (MLA)

Zeleke, Gemechu…[et al.]. In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice. Journal of Parasitology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1186198

American Medical Association (AMA)

Zeleke, Gemechu& Kebebe, Dereje& Mulisa Bobasa, Eshetu& Gashe Fufa, Fanta. In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice. Journal of Parasitology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1186198

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1186198