Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors
المؤلفون المشاركون
Guo, Qie
Li, Xiao
Cui, Meng-Na
Liang, Yu
Li, Xiang-Peng
Zhao, Jun
Wei, Li-Na
Zhang, Xiao-Lei
Quan, Xiang Hua
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A pterygium is generally believed to be a chronic inflammatory lesion caused by external stimuli that develops from the conjunctiva and grows onto the cornea.
Simple bare sclera excision is the most commonly used method to treat pterygium.
However, the high postoperative recurrence rate of pterygium remains a persistent challenge.
Mitomycin C (MMC) is an antineoplastic antibiotic that inhibits DNA, RNA, and protein synthesis.
In recent years, although MMC has proven useful for the treatment of pterygium, its application has been controversial because of its clear toxicity and the possibility of ocular complications.
In the current study, we prospectively recruited patients to receive or not receive a local injection of MMC (0.4 mg/ml).
Follow-up was conducted with the patients to determine the postoperative recurrence rate of pterygium and/or to observe any ocular complications.
The remarkable results demonstrated that MMC can decrease the postoperative recurrence rate of pterygium without leading to serious eye complications.
Further results indicated that MMC can inhibit the activation of the NLRP3 inflammatory signalling pathway and thus downregulate the expression of downstream molecules, including IL-18 and IL-1β.
MMC also reduced the expression of inflammatory factors TGF-β1, VEGF, and IL-6.
In addition to influencing these factors, MMC suppressed neovascularization and the proliferation of corneal fibroblasts to effectively reduce the recurrence rate of pterygium.
Taken together, our results provide a theoretical basis for the development of prevention and treatment strategies for pterygium and suggest that MMC is highly effective as an adjunctive treatment after excision of primary pterygia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Qie& Li, Xiao& Cui, Meng-Na& Liang, Yu& Li, Xiang-Peng& Zhao, Jun…[et al.]. 2019. Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1186459
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Qie…[et al.]. Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors. Journal of Ophthalmology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1186459
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Qie& Li, Xiao& Cui, Meng-Na& Liang, Yu& Li, Xiang-Peng& Zhao, Jun…[et al.]. Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1186459
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1186459
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر