Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors
Joint Authors
Guo, Qie
Li, Xiao
Cui, Meng-Na
Liang, Yu
Li, Xiang-Peng
Zhao, Jun
Wei, Li-Na
Zhang, Xiao-Lei
Quan, Xiang Hua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A pterygium is generally believed to be a chronic inflammatory lesion caused by external stimuli that develops from the conjunctiva and grows onto the cornea.
Simple bare sclera excision is the most commonly used method to treat pterygium.
However, the high postoperative recurrence rate of pterygium remains a persistent challenge.
Mitomycin C (MMC) is an antineoplastic antibiotic that inhibits DNA, RNA, and protein synthesis.
In recent years, although MMC has proven useful for the treatment of pterygium, its application has been controversial because of its clear toxicity and the possibility of ocular complications.
In the current study, we prospectively recruited patients to receive or not receive a local injection of MMC (0.4 mg/ml).
Follow-up was conducted with the patients to determine the postoperative recurrence rate of pterygium and/or to observe any ocular complications.
The remarkable results demonstrated that MMC can decrease the postoperative recurrence rate of pterygium without leading to serious eye complications.
Further results indicated that MMC can inhibit the activation of the NLRP3 inflammatory signalling pathway and thus downregulate the expression of downstream molecules, including IL-18 and IL-1β.
MMC also reduced the expression of inflammatory factors TGF-β1, VEGF, and IL-6.
In addition to influencing these factors, MMC suppressed neovascularization and the proliferation of corneal fibroblasts to effectively reduce the recurrence rate of pterygium.
Taken together, our results provide a theoretical basis for the development of prevention and treatment strategies for pterygium and suggest that MMC is highly effective as an adjunctive treatment after excision of primary pterygia.
American Psychological Association (APA)
Guo, Qie& Li, Xiao& Cui, Meng-Na& Liang, Yu& Li, Xiang-Peng& Zhao, Jun…[et al.]. 2019. Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1186459
Modern Language Association (MLA)
Guo, Qie…[et al.]. Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors. Journal of Ophthalmology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1186459
American Medical Association (AMA)
Guo, Qie& Li, Xiao& Cui, Meng-Na& Liang, Yu& Li, Xiang-Peng& Zhao, Jun…[et al.]. Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1186459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186459