A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice
المؤلفون المشاركون
Wang, Yong
Cui, Xuemei
Yuan, Lijia
Maqbool, Babar
Xu, Wei
He, Shanshan
Guan, Ran
Hu, Songhua
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Pseudorabies is an important infectious disease of swine, and immunization using attenuated pseudorabies virus (aPrV) vaccine is a routine practice to control this disease in swine herds.
This study was to evaluate a saline solution containing ginseng stem-leaf saponins (GSLS) and sodium selenite (Se) as a vaccine adjuvant for its enhancement of immune response to aPrV vaccine.
The results showed that aPrV vaccine diluted with saline containing GSLS-Se (aP-GSe) induced significantly higher immune responses than that of the vaccine diluted with saline alone (aP-S).
The aP-GSe promoted higher production of gB-specific IgG, IgG1, and IgG2a, neutralizing antibody titers, secretion of Th1-type (IFN-γ, IL-2, IL-12), and Th2-type (IL-4, IL-6, IL-10) cytokines, and upregulated the T-bet/GATA-3 mRNA expression when compared to aP-S.
In addition, cytolytic activity of NK cells, lymphocyte proliferation, and CD4+/CD8+ ratio was also significantly increased by aP-GSe.
More importantly, aP-GSe conferred a much higher resistance of mice to a field virulent pseudorabies virus (fPrV) challenge.
As the present study was conducted in mice, further study is required to evaluate the aP-GSe to improve the vaccination against PrV in swine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yong& Cui, Xuemei& Yuan, Lijia& Maqbool, Babar& Xu, Wei& He, Shanshan…[et al.]. 2020. A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yong…[et al.]. A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice. Journal of Immunology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yong& Cui, Xuemei& Yuan, Lijia& Maqbool, Babar& Xu, Wei& He, Shanshan…[et al.]. A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر