A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice
Joint Authors
Wang, Yong
Cui, Xuemei
Yuan, Lijia
Maqbool, Babar
Xu, Wei
He, Shanshan
Guan, Ran
Hu, Songhua
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pseudorabies is an important infectious disease of swine, and immunization using attenuated pseudorabies virus (aPrV) vaccine is a routine practice to control this disease in swine herds.
This study was to evaluate a saline solution containing ginseng stem-leaf saponins (GSLS) and sodium selenite (Se) as a vaccine adjuvant for its enhancement of immune response to aPrV vaccine.
The results showed that aPrV vaccine diluted with saline containing GSLS-Se (aP-GSe) induced significantly higher immune responses than that of the vaccine diluted with saline alone (aP-S).
The aP-GSe promoted higher production of gB-specific IgG, IgG1, and IgG2a, neutralizing antibody titers, secretion of Th1-type (IFN-γ, IL-2, IL-12), and Th2-type (IL-4, IL-6, IL-10) cytokines, and upregulated the T-bet/GATA-3 mRNA expression when compared to aP-S.
In addition, cytolytic activity of NK cells, lymphocyte proliferation, and CD4+/CD8+ ratio was also significantly increased by aP-GSe.
More importantly, aP-GSe conferred a much higher resistance of mice to a field virulent pseudorabies virus (fPrV) challenge.
As the present study was conducted in mice, further study is required to evaluate the aP-GSe to improve the vaccination against PrV in swine.
American Psychological Association (APA)
Wang, Yong& Cui, Xuemei& Yuan, Lijia& Maqbool, Babar& Xu, Wei& He, Shanshan…[et al.]. 2020. A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187071
Modern Language Association (MLA)
Wang, Yong…[et al.]. A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice. Journal of Immunology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187071
American Medical Association (AMA)
Wang, Yong& Cui, Xuemei& Yuan, Lijia& Maqbool, Babar& Xu, Wei& He, Shanshan…[et al.]. A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1Th2 Immune Responses in Mice. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187071