Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations
المؤلفون المشاركون
Xu, Jian
Cheng, Yuqi
Xu, Xiufeng
Liu, Shuang
Zhao, Yueyin
Xie, Zhongqi
Lu, Zhaoping
Lai, Aiyun
Upreti, Bibhuti
Wang, Xiangyu
Luo, Chunrong
Yu, Hongjun
Shan, Bao-Ci
Xu, Lin
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status, and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE).
Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited.
All participants underwent the standard high-resolution volumetric MRI.
The bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated, respectively, for each participant.
We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of the HC group.
The bilateral HIPV of female patients were significantly less than those of male patients.
The SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD.
Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD.
Hydroxychloroquine (HCQ) showed a protective effect on right HIPV.
In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages.
Early detection and intervention of hippocampal damage might prevent the progression to NPSLE.
More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Shuang& Cheng, Yuqi& Zhao, Yueyin& Lai, Aiyun& Lu, Zhaoping& Xie, Zhongqi…[et al.]. 2020. Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Shuang…[et al.]. Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1187097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Shuang& Cheng, Yuqi& Zhao, Yueyin& Lai, Aiyun& Lu, Zhaoping& Xie, Zhongqi…[et al.]. Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر