Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations
Joint Authors
Xu, Jian
Cheng, Yuqi
Xu, Xiufeng
Liu, Shuang
Zhao, Yueyin
Xie, Zhongqi
Lu, Zhaoping
Lai, Aiyun
Upreti, Bibhuti
Wang, Xiangyu
Luo, Chunrong
Yu, Hongjun
Shan, Bao-Ci
Xu, Lin
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status, and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE).
Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited.
All participants underwent the standard high-resolution volumetric MRI.
The bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated, respectively, for each participant.
We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of the HC group.
The bilateral HIPV of female patients were significantly less than those of male patients.
The SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD.
Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD.
Hydroxychloroquine (HCQ) showed a protective effect on right HIPV.
In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages.
Early detection and intervention of hippocampal damage might prevent the progression to NPSLE.
More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.
American Psychological Association (APA)
Liu, Shuang& Cheng, Yuqi& Zhao, Yueyin& Lai, Aiyun& Lu, Zhaoping& Xie, Zhongqi…[et al.]. 2020. Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187097
Modern Language Association (MLA)
Liu, Shuang…[et al.]. Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1187097
American Medical Association (AMA)
Liu, Shuang& Cheng, Yuqi& Zhao, Yueyin& Lai, Aiyun& Lu, Zhaoping& Xie, Zhongqi…[et al.]. Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187097