Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction
المؤلفون المشاركون
Moreno-Ruíz, Luis Antonio
Garza-Reyes, Montserrat Guadalupe
Mora-Ruíz, Mónica Daniela
Chávez-Sánchez, Luis
Madrid-Miller, Alejandra
Cabrera-Quintero, Alberto Jose
Maravillas-Montero, José Luis
Zentella-Dehesa, Alejandro
Pastor-Salgado, Selene
Ramírez-Arias, Erick
Pérez-Velázquez, Nataly
Blanco-Favela, Francisco
Vazquez-Gonzalez, Wendy Guadalupe
Contreras-Rodríguez, Alicia
Chávez-Rueda, Adriana Karina
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes.
Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI.
We analyzed the circulating levels of IL-17 in patient plasma.
A gradual increase in IL-17 was found in STEMI and post-STEMI patients.
Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI.
Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI.
Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI.
Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Garza-Reyes, Montserrat Guadalupe& Mora-Ruíz, Mónica Daniela& Chávez-Sánchez, Luis& Madrid-Miller, Alejandra& Cabrera-Quintero, Alberto Jose& Maravillas-Montero, José Luis…[et al.]. 2020. Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Garza-Reyes, Montserrat Guadalupe…[et al.]. Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Garza-Reyes, Montserrat Guadalupe& Mora-Ruíz, Mónica Daniela& Chávez-Sánchez, Luis& Madrid-Miller, Alejandra& Cabrera-Quintero, Alberto Jose& Maravillas-Montero, José Luis…[et al.]. Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر