Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction
Joint Authors
Moreno-Ruíz, Luis Antonio
Garza-Reyes, Montserrat Guadalupe
Mora-Ruíz, Mónica Daniela
Chávez-Sánchez, Luis
Madrid-Miller, Alejandra
Cabrera-Quintero, Alberto Jose
Maravillas-Montero, José Luis
Zentella-Dehesa, Alejandro
Pastor-Salgado, Selene
Ramírez-Arias, Erick
Pérez-Velázquez, Nataly
Blanco-Favela, Francisco
Vazquez-Gonzalez, Wendy Guadalupe
Contreras-Rodríguez, Alicia
Chávez-Rueda, Adriana Karina
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes.
Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI.
We analyzed the circulating levels of IL-17 in patient plasma.
A gradual increase in IL-17 was found in STEMI and post-STEMI patients.
Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI.
Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI.
Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI.
Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.
American Psychological Association (APA)
Garza-Reyes, Montserrat Guadalupe& Mora-Ruíz, Mónica Daniela& Chávez-Sánchez, Luis& Madrid-Miller, Alejandra& Cabrera-Quintero, Alberto Jose& Maravillas-Montero, José Luis…[et al.]. 2020. Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187316
Modern Language Association (MLA)
Garza-Reyes, Montserrat Guadalupe…[et al.]. Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187316
American Medical Association (AMA)
Garza-Reyes, Montserrat Guadalupe& Mora-Ruíz, Mónica Daniela& Chávez-Sánchez, Luis& Madrid-Miller, Alejandra& Cabrera-Quintero, Alberto Jose& Maravillas-Montero, José Luis…[et al.]. Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187316