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Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis
المؤلفون المشاركون
Wang, Yunxiu
Cao, Zhiwei
Zhao, He
Ren, Yaoyao
Hao, Liying
Gu, Zhaowei
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
Bisphenol A (BPA) is found in many plastic products and is thus a common environmental endocrine disruptor.
Plastic-related health problems, including allergic diseases, are attracting increasing attention.
However, few experimental studies have explored the effect of BPA on allergic rhinitis (AR).
We explore whether BPA was directly related to the allergic inflammation induced by ovalbumin (OVA) in AR mice.
Methods.
We first constructed OVA-induced mouse model, and after BPA administration, we evaluated nasal symptoms and measured the serum OVA-specific IgE levels by ELISA.
Th2 and Treg-related cytokines of nasal mucosa were measured by cytometric bead array.
Th2 and Treg-specific transcription factor levels were assayed by PCR.
The proportions of CD3+CD4+IL-4+Th2 and CD4+Helios+Foxp3+ T cells (Tregs) in spleen tissue were determined by flow cytometry.
Results.
Compared to OVA-only-induced mice, BPA addition increased nasal symptoms and serum OVA-specific IgE levels.
OVA and BPA coexposure significantly increased IL-4 and IL-13 protein levels compared to those after OVA exposure alone.
BPA plus OVA tended to decrease the IL-10 protein levels compared to those after OVA alone.
Coexposure to OVA and BPA significantly increased the GATA-3-encoding mRNA level, and decreased the levels of mRNAs encoding Foxp3 and Helios, compared to those after OVA exposure alone.
BPA increased the Th2 cell proportion, and decreased that of Tregs, compared to the levels with OVA alone.
Conclusion.
BPA exerted negative effects by exacerbating AR allergic symptoms, increasing serum OVA-specific IgE levels, and compromising Th2 and Treg responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yunxiu& Cao, Zhiwei& Zhao, He& Ren, Yaoyao& Hao, Liying& Gu, Zhaowei. 2020. Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187476
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yunxiu…[et al.]. Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187476
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yunxiu& Cao, Zhiwei& Zhao, He& Ren, Yaoyao& Hao, Liying& Gu, Zhaowei. Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187476
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187476
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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