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Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis
Joint Authors
Wang, Yunxiu
Cao, Zhiwei
Zhao, He
Ren, Yaoyao
Hao, Liying
Gu, Zhaowei
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Bisphenol A (BPA) is found in many plastic products and is thus a common environmental endocrine disruptor.
Plastic-related health problems, including allergic diseases, are attracting increasing attention.
However, few experimental studies have explored the effect of BPA on allergic rhinitis (AR).
We explore whether BPA was directly related to the allergic inflammation induced by ovalbumin (OVA) in AR mice.
Methods.
We first constructed OVA-induced mouse model, and after BPA administration, we evaluated nasal symptoms and measured the serum OVA-specific IgE levels by ELISA.
Th2 and Treg-related cytokines of nasal mucosa were measured by cytometric bead array.
Th2 and Treg-specific transcription factor levels were assayed by PCR.
The proportions of CD3+CD4+IL-4+Th2 and CD4+Helios+Foxp3+ T cells (Tregs) in spleen tissue were determined by flow cytometry.
Results.
Compared to OVA-only-induced mice, BPA addition increased nasal symptoms and serum OVA-specific IgE levels.
OVA and BPA coexposure significantly increased IL-4 and IL-13 protein levels compared to those after OVA exposure alone.
BPA plus OVA tended to decrease the IL-10 protein levels compared to those after OVA alone.
Coexposure to OVA and BPA significantly increased the GATA-3-encoding mRNA level, and decreased the levels of mRNAs encoding Foxp3 and Helios, compared to those after OVA exposure alone.
BPA increased the Th2 cell proportion, and decreased that of Tregs, compared to the levels with OVA alone.
Conclusion.
BPA exerted negative effects by exacerbating AR allergic symptoms, increasing serum OVA-specific IgE levels, and compromising Th2 and Treg responses.
American Psychological Association (APA)
Wang, Yunxiu& Cao, Zhiwei& Zhao, He& Ren, Yaoyao& Hao, Liying& Gu, Zhaowei. 2020. Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187476
Modern Language Association (MLA)
Wang, Yunxiu…[et al.]. Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187476
American Medical Association (AMA)
Wang, Yunxiu& Cao, Zhiwei& Zhao, He& Ren, Yaoyao& Hao, Liying& Gu, Zhaowei. Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187476