Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV
المؤلفون المشاركون
Giaquinto, C.
Dalzini, Annalisa
Petrara, Maria Raffaella
Ballin, Giovanni
Zanchetta, Marisa
De Rossi, Anita
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Chronic HIV-infected children suffer from premature aging and aging-related diseases.
Viral replication induces an ongoing inflammation process, with the release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), the activation of the immune system, and the production of proinflammatory cytokines.
Although combined highly active antiretroviral therapy (ART) has significantly modified the natural course of HIV infection, normalization of T and B cell phenotype is not completely achievable; thus, many HIV-infected children display several phenotypical alterations, including higher percentages of activated cells, that favor an accelerated telomere attrition, and higher percentages of exhausted and senescent cells.
All these features ultimately lead to the clinical manifestations related to premature aging and comorbidities typically observed in older general population, including non-AIDS-related malignancies.
Therefore, even under effective treatment, the premature aging process of HIV-infected children negatively impacts their quality and length of life.
This review examines the available data on the impact of HIV and ART on immune and biological senescence of HIV-infected children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dalzini, Annalisa& Petrara, Maria Raffaella& Ballin, Giovanni& Zanchetta, Marisa& Giaquinto, C.& De Rossi, Anita. 2020. Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1187501
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dalzini, Annalisa…[et al.]. Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV. Journal of Immunology Research No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1187501
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dalzini, Annalisa& Petrara, Maria Raffaella& Ballin, Giovanni& Zanchetta, Marisa& Giaquinto, C.& De Rossi, Anita. Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1187501
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187501
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر