Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV
Joint Authors
Giaquinto, C.
Dalzini, Annalisa
Petrara, Maria Raffaella
Ballin, Giovanni
Zanchetta, Marisa
De Rossi, Anita
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chronic HIV-infected children suffer from premature aging and aging-related diseases.
Viral replication induces an ongoing inflammation process, with the release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), the activation of the immune system, and the production of proinflammatory cytokines.
Although combined highly active antiretroviral therapy (ART) has significantly modified the natural course of HIV infection, normalization of T and B cell phenotype is not completely achievable; thus, many HIV-infected children display several phenotypical alterations, including higher percentages of activated cells, that favor an accelerated telomere attrition, and higher percentages of exhausted and senescent cells.
All these features ultimately lead to the clinical manifestations related to premature aging and comorbidities typically observed in older general population, including non-AIDS-related malignancies.
Therefore, even under effective treatment, the premature aging process of HIV-infected children negatively impacts their quality and length of life.
This review examines the available data on the impact of HIV and ART on immune and biological senescence of HIV-infected children.
American Psychological Association (APA)
Dalzini, Annalisa& Petrara, Maria Raffaella& Ballin, Giovanni& Zanchetta, Marisa& Giaquinto, C.& De Rossi, Anita. 2020. Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1187501
Modern Language Association (MLA)
Dalzini, Annalisa…[et al.]. Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV. Journal of Immunology Research No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1187501
American Medical Association (AMA)
Dalzini, Annalisa& Petrara, Maria Raffaella& Ballin, Giovanni& Zanchetta, Marisa& Giaquinto, C.& De Rossi, Anita. Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1187501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187501