Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications
المؤلفون المشاركون
Madaghiele, M.
Demitri, C.
Sannino, A.
Bonfrate, Valentina
Salvatore, Luca
Nitti, Paola
Carofiglio, Vito Emanuele
Stufano, Paolo
Calò, Emanuela
Scarlino, Stefania
Centrone, Domenico
Cascione, Mariafrancesca
Leporatti, Stefano
المصدر
Journal of Healthcare Engineering
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In this work, tunable nonwoven mats based on poly(3-hydroxybutyrate) (PHB) and type I collagen (Coll) were successfully produced by electrospinning.
The PHB/Coll weight ratio (fixed at 100/0, 70/30, and 50/50, resp.) was found to control the morphological, thermal, mechanical, and degradation properties of the mats.
Increasing collagen amounts led to larger diameters of the fibers (in the approximate range 600–900 nm), while delaying their thermal decomposition (from 245°C to 262°C).
Collagen also accelerated the hydrolytic degradation of the mats upon incubation in aqueous medium at 37°C for 23 days (with final weight losses of 1%, 15%, and 23% for 100/0, 70/30, and 50/50 samples, resp.), as a result of increased mat wettability and reduced PHB crystallinity.
Interestingly, 70/30 meshes were the ones displaying the lowest stiffness (~116 MPa; p<0.05 versus 100/0 and 50/50 meshes), while 50/50 samples had an elastic modulus comparable to that of 100/0 ones (~250 MPa), likely due to enhanced physical crosslinking of the collagen chains, at least at high protein amounts.
All substrates were also found to allow for good viability and proliferation of murine fibroblasts, up to 6 days of culture.
Collectively, the results evidenced the potential of as-spun PHB/Coll meshes for tissue engineering applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salvatore, Luca& Carofiglio, Vito Emanuele& Stufano, Paolo& Bonfrate, Valentina& Calò, Emanuela& Scarlino, Stefania…[et al.]. 2018. Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications. Journal of Healthcare Engineering،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1187516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salvatore, Luca…[et al.]. Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications. Journal of Healthcare Engineering No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1187516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salvatore, Luca& Carofiglio, Vito Emanuele& Stufano, Paolo& Bonfrate, Valentina& Calò, Emanuela& Scarlino, Stefania…[et al.]. Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications. Journal of Healthcare Engineering. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1187516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر