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Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications
Joint Authors
Madaghiele, M.
Demitri, C.
Sannino, A.
Bonfrate, Valentina
Salvatore, Luca
Nitti, Paola
Carofiglio, Vito Emanuele
Stufano, Paolo
Calò, Emanuela
Scarlino, Stefania
Centrone, Domenico
Cascione, Mariafrancesca
Leporatti, Stefano
Source
Journal of Healthcare Engineering
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In this work, tunable nonwoven mats based on poly(3-hydroxybutyrate) (PHB) and type I collagen (Coll) were successfully produced by electrospinning.
The PHB/Coll weight ratio (fixed at 100/0, 70/30, and 50/50, resp.) was found to control the morphological, thermal, mechanical, and degradation properties of the mats.
Increasing collagen amounts led to larger diameters of the fibers (in the approximate range 600–900 nm), while delaying their thermal decomposition (from 245°C to 262°C).
Collagen also accelerated the hydrolytic degradation of the mats upon incubation in aqueous medium at 37°C for 23 days (with final weight losses of 1%, 15%, and 23% for 100/0, 70/30, and 50/50 samples, resp.), as a result of increased mat wettability and reduced PHB crystallinity.
Interestingly, 70/30 meshes were the ones displaying the lowest stiffness (~116 MPa; p<0.05 versus 100/0 and 50/50 meshes), while 50/50 samples had an elastic modulus comparable to that of 100/0 ones (~250 MPa), likely due to enhanced physical crosslinking of the collagen chains, at least at high protein amounts.
All substrates were also found to allow for good viability and proliferation of murine fibroblasts, up to 6 days of culture.
Collectively, the results evidenced the potential of as-spun PHB/Coll meshes for tissue engineering applications.
American Psychological Association (APA)
Salvatore, Luca& Carofiglio, Vito Emanuele& Stufano, Paolo& Bonfrate, Valentina& Calò, Emanuela& Scarlino, Stefania…[et al.]. 2018. Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications. Journal of Healthcare Engineering،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1187516
Modern Language Association (MLA)
Salvatore, Luca…[et al.]. Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications. Journal of Healthcare Engineering No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1187516
American Medical Association (AMA)
Salvatore, Luca& Carofiglio, Vito Emanuele& Stufano, Paolo& Bonfrate, Valentina& Calò, Emanuela& Scarlino, Stefania…[et al.]. Potential of Electrospun Poly(3-hydroxybutyrate)Collagen Blends for Tissue Engineering Applications. Journal of Healthcare Engineering. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1187516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187516