Large-Scale Screening in General Population Children for Celiac Disease with a Multiplex Electrochemiluminescence (ECL) Assay
المؤلفون المشاركون
Rewers, Marian
Miao, Dongmei
Waugh, Kathleen
Gu, Yong
He, Ling
Jia, Xiaofan
Geno, Cristy
Yu, Liping
Liu, Edwin
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Autoimmunity Screening for Kids (ASK) study was launched to screen general population children for type 1 diabetes (T1D) and celiac disease (CD).
Methods.
A total of 23,319 children from general population were screened.
A high throughput multiplex electrochemiluminescence (ECL) assay to screen multiautoantibodies in a single well was applied, parallel with a standard radiobinding assay (RBA).
All children with any positive autoantibodies in screening were revisited within one month for confirmation and followed every 6 months.
Results.
Among 23,319 children, 2.6% (606/23,319) of children were tested positive for TGA.
Multiplex ECL assay detected more TGA (584/23,319) in the initial screening than RBA (490/23,319, p=0.004) and was able to detect TGA earlier than RBA in a subset of children by 0.8 to 34.8 months.
Prevalence of TGA by either ECL or RBA in children with islet autoantibodies was found significantly higher than overall prevalence in general population screened.
Conclusions.
A multiplex ECL assay was more sensitive than standard RBA by identifying more TGA positivity and detecting TGA earlier in general population screening.
It also provides a high efficient tool with its unique advantage of multiplexing measurements to screen for multiple autoimmune diseases simultaneously in general population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Ling& Jia, Xiaofan& Gu, Yong& Miao, Dongmei& Waugh, Kathleen& Geno, Cristy…[et al.]. 2020. Large-Scale Screening in General Population Children for Celiac Disease with a Multiplex Electrochemiluminescence (ECL) Assay. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1187644
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Ling…[et al.]. Large-Scale Screening in General Population Children for Celiac Disease with a Multiplex Electrochemiluminescence (ECL) Assay. Journal of Immunology Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1187644
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Ling& Jia, Xiaofan& Gu, Yong& Miao, Dongmei& Waugh, Kathleen& Geno, Cristy…[et al.]. Large-Scale Screening in General Population Children for Celiac Disease with a Multiplex Electrochemiluminescence (ECL) Assay. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1187644
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187644
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر