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Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics
المؤلفون المشاركون
Elhag, Mustafa
Alaagib, Ruaa Mohamed
Ahmed, Nagla Mohamed
Abubaker, Mustafa
Haroun, Esraa Musa
Albagi, Sahar Obi Abd
Hassan, Mohammed A.
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Pseudomonas aeruginosa is a common pathogen that is responsible for serious hospital-acquired infections, ventilator-associated pneumonia, and various sepsis syndromes.
Also, it is a multidrug-resistant pathogen recognized for its ubiquity and its intrinsically advanced antibiotic-resistant mechanisms.
It usually affects immunocompromised individuals but can also infect immunocompetent individuals.
There is no vaccine against it available till now.
This study predicts an effective epitope-based vaccine against fructose bisphosphate aldolase (FBA) of Pseudomonas aeruginosa using immunoinformatics tools.
The protein sequences were obtained from NCBI, and prediction tests were undertaken to analyze possible epitopes for B and T cells.
Three B cell epitopes passed the antigenicity, accessibility, and hydrophilicity tests.
Six MHC I epitopes were found to be promising, while four MHC II epitopes were found promising from the result set.
Nineteen epitopes were shared between MHC I and II results.
For the population coverage, the epitopes covered 95.62% worldwide excluding certain MHC II alleles.
We recommend in vivo and in vitro studies to prove its effectiveness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elhag, Mustafa& Alaagib, Ruaa Mohamed& Ahmed, Nagla Mohamed& Abubaker, Mustafa& Haroun, Esraa Musa& Albagi, Sahar Obi Abd…[et al.]. 2020. Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elhag, Mustafa…[et al.]. Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elhag, Mustafa& Alaagib, Ruaa Mohamed& Ahmed, Nagla Mohamed& Abubaker, Mustafa& Haroun, Esraa Musa& Albagi, Sahar Obi Abd…[et al.]. Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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