Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach
المؤلفون المشاركون
Baharum, Syarul Nataqain
Ahmad, Siti Junaidah
Abdul Rahim, Mohd Badrin Hanizam
Baba, Mohd Shukri
Zin, Noraziah Mohamad
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Natural products continue to play an important role as a source of biologically active substances for the development of new drug.
Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics.
Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria.
However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process.
Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products.
Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process.
The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds.
The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products.
Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Siti Junaidah& Abdul Rahim, Mohd Badrin Hanizam& Baharum, Syarul Nataqain& Baba, Mohd Shukri& Zin, Noraziah Mohamad. 2017. Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1187930
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Siti Junaidah…[et al.]. Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1187930
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Siti Junaidah& Abdul Rahim, Mohd Badrin Hanizam& Baharum, Syarul Nataqain& Baba, Mohd Shukri& Zin, Noraziah Mohamad. Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1187930
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187930
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر