Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach
Joint Authors
Baharum, Syarul Nataqain
Ahmad, Siti Junaidah
Abdul Rahim, Mohd Badrin Hanizam
Baba, Mohd Shukri
Zin, Noraziah Mohamad
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Natural products continue to play an important role as a source of biologically active substances for the development of new drug.
Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics.
Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria.
However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process.
Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products.
Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process.
The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds.
The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products.
Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.
American Psychological Association (APA)
Ahmad, Siti Junaidah& Abdul Rahim, Mohd Badrin Hanizam& Baharum, Syarul Nataqain& Baba, Mohd Shukri& Zin, Noraziah Mohamad. 2017. Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1187930
Modern Language Association (MLA)
Ahmad, Siti Junaidah…[et al.]. Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1187930
American Medical Association (AMA)
Ahmad, Siti Junaidah& Abdul Rahim, Mohd Badrin Hanizam& Baharum, Syarul Nataqain& Baba, Mohd Shukri& Zin, Noraziah Mohamad. Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1187930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187930