Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines
المؤلفون المشاركون
Slattery, Patrick
Linke, Bona
Schreiber, Yannick
Picard-Willems, Bettina
Nüsing, Rolf M.
Harder, Sebastian
Geisslinger, Gerd
Scholich, Klaus
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Platelets are well known for their role in hemostasis and are also increasingly recognized for their roles in the innate immune system during inflammation and their regulation of macrophage activation.
Here, we aimed to study the influence of platelets on the production of inflammatory mediators by monocytes and macrophages.
Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) α secretion out of the monocytes or macrophages.
Platelet PGE2 mediated the upregulation of IL-10 in both cell types via the PGE2 receptor EP2.
Notably, PGE2-mediated IL-10 synthesis was also mediated by EP4 in murine macrophages.
Inhibition of TNFα synthesis via EP2 and EP4, but not EP1, was mediated by IL-10, since blockade of the IL-10 receptor abolished the inhibitory effect of both receptors on TNFα release.
This platelet-mediated cross-regulation between PGE2 and cytokines reveals one mechanism how monocytes and macrophages can attenuate excessive inflammatory responses induced by activated platelets in order to limit inflammatory processes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Linke, Bona& Schreiber, Yannick& Picard-Willems, Bettina& Slattery, Patrick& Nüsing, Rolf M.& Harder, Sebastian…[et al.]. 2017. Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Linke, Bona…[et al.]. Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Linke, Bona& Schreiber, Yannick& Picard-Willems, Bettina& Slattery, Patrick& Nüsing, Rolf M.& Harder, Sebastian…[et al.]. Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر