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Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines
Joint Authors
Slattery, Patrick
Linke, Bona
Schreiber, Yannick
Picard-Willems, Bettina
Nüsing, Rolf M.
Harder, Sebastian
Geisslinger, Gerd
Scholich, Klaus
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Platelets are well known for their role in hemostasis and are also increasingly recognized for their roles in the innate immune system during inflammation and their regulation of macrophage activation.
Here, we aimed to study the influence of platelets on the production of inflammatory mediators by monocytes and macrophages.
Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) α secretion out of the monocytes or macrophages.
Platelet PGE2 mediated the upregulation of IL-10 in both cell types via the PGE2 receptor EP2.
Notably, PGE2-mediated IL-10 synthesis was also mediated by EP4 in murine macrophages.
Inhibition of TNFα synthesis via EP2 and EP4, but not EP1, was mediated by IL-10, since blockade of the IL-10 receptor abolished the inhibitory effect of both receptors on TNFα release.
This platelet-mediated cross-regulation between PGE2 and cytokines reveals one mechanism how monocytes and macrophages can attenuate excessive inflammatory responses induced by activated platelets in order to limit inflammatory processes.
American Psychological Association (APA)
Linke, Bona& Schreiber, Yannick& Picard-Willems, Bettina& Slattery, Patrick& Nüsing, Rolf M.& Harder, Sebastian…[et al.]. 2017. Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188079
Modern Language Association (MLA)
Linke, Bona…[et al.]. Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188079
American Medical Association (AMA)
Linke, Bona& Schreiber, Yannick& Picard-Willems, Bettina& Slattery, Patrick& Nüsing, Rolf M.& Harder, Sebastian…[et al.]. Activated Platelets Induce an Anti-Inflammatory Response of MonocytesMacrophages through Cross-Regulation of PGE2 and Cytokines. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188079