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Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells
المؤلفون المشاركون
Schiumarini, Domitilla
Loberto, Nicoletta
Mancini, Giulia
Bassi, Rosaria
Giussani, Paola
Chiricozzi, Elena
Samarani, Maura
Munari, Silvia
Tamanini, Anna
Cabrini, Giulio
Dechecchi, Maria Cristina
Sonnino, Sandro
Aureli, Massimo
Lippi, Giuseppe
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-03
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Cystic fibrosis (CF) is the most common autosomal genetic recessive disease caused by mutations of gene encoding for the cystic fibrosis transmembrane conductance regulator.
Patients with CF display a wide spectrum of symptoms, the most severe being chronic lung infection and inflammation, which lead to onset of cystic fibrosis lung disease.
Several studies indicate that sphingolipids play a regulatory role in airway inflammation.
The inhibition and downregulation of GBA2, the enzyme catabolizing glucosylceramide to ceramide, are associated with a significant reduction of IL-8 production in CF bronchial epithelial cells.
Herein, we demonstrate that GBA2 plays a role in the proinflammatory state characterizing CF cells.
We also report for the first time that Pseudomonas aeruginosa infection causes a recruitment of plasma membrane-associated glycosphingolipid hydrolases into lipid rafts of CuFi-1-infected cells.
This reorganization of cell membrane may be responsible for activation of a signaling cascade, culminating in aberrant inflammatory response in CF bronchial epithelial cells upon bacterial infection.
Taken together, the presented data further support the role of sphingolipids and their metabolic enzymes in controlling the inflammatory response in CF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schiumarini, Domitilla& Loberto, Nicoletta& Mancini, Giulia& Bassi, Rosaria& Giussani, Paola& Chiricozzi, Elena…[et al.]. 2017. Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188113
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schiumarini, Domitilla…[et al.]. Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188113
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schiumarini, Domitilla& Loberto, Nicoletta& Mancini, Giulia& Bassi, Rosaria& Giussani, Paola& Chiricozzi, Elena…[et al.]. Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188113
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188113
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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