![](/images/graphics-bg.png)
Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells
Joint Authors
Schiumarini, Domitilla
Loberto, Nicoletta
Mancini, Giulia
Bassi, Rosaria
Giussani, Paola
Chiricozzi, Elena
Samarani, Maura
Munari, Silvia
Tamanini, Anna
Cabrini, Giulio
Dechecchi, Maria Cristina
Sonnino, Sandro
Aureli, Massimo
Lippi, Giuseppe
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cystic fibrosis (CF) is the most common autosomal genetic recessive disease caused by mutations of gene encoding for the cystic fibrosis transmembrane conductance regulator.
Patients with CF display a wide spectrum of symptoms, the most severe being chronic lung infection and inflammation, which lead to onset of cystic fibrosis lung disease.
Several studies indicate that sphingolipids play a regulatory role in airway inflammation.
The inhibition and downregulation of GBA2, the enzyme catabolizing glucosylceramide to ceramide, are associated with a significant reduction of IL-8 production in CF bronchial epithelial cells.
Herein, we demonstrate that GBA2 plays a role in the proinflammatory state characterizing CF cells.
We also report for the first time that Pseudomonas aeruginosa infection causes a recruitment of plasma membrane-associated glycosphingolipid hydrolases into lipid rafts of CuFi-1-infected cells.
This reorganization of cell membrane may be responsible for activation of a signaling cascade, culminating in aberrant inflammatory response in CF bronchial epithelial cells upon bacterial infection.
Taken together, the presented data further support the role of sphingolipids and their metabolic enzymes in controlling the inflammatory response in CF.
American Psychological Association (APA)
Schiumarini, Domitilla& Loberto, Nicoletta& Mancini, Giulia& Bassi, Rosaria& Giussani, Paola& Chiricozzi, Elena…[et al.]. 2017. Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188113
Modern Language Association (MLA)
Schiumarini, Domitilla…[et al.]. Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188113
American Medical Association (AMA)
Schiumarini, Domitilla& Loberto, Nicoletta& Mancini, Giulia& Bassi, Rosaria& Giussani, Paola& Chiricozzi, Elena…[et al.]. Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188113