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Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells
المؤلفون المشاركون
Layseca-Espinosa, Esther
Vitales-Noyola, Marlen
Oceguera-Maldonado, Brenda
Niño-Moreno, Perla
Baltazar-Benítez, Nubia
Abud-Mendoza, Carlos
González-Amaro, Roberto
Baranda, Lourdes
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
T regulatory (Treg) cells have a key role in the pathogenesis of chronic inflammatory and autoimmune diseases.
A CD4+CD69+ T cell subset has been described that behaves as Treg lymphocytes, exerting an important immune suppressive effect.
In this study, we analyzed the levels and function of CD4+CD69+ Treg cells in patients with systemic lupus erythematosus (SLE).
Blood samples were obtained from 22 patients with SLE and 25 healthy subjects.
Levels of CD4+CD69+ Treg cells were analyzed by multiparametric flow cytometry, and their function was measured by an assay of suppression of lymphocyte activation and through the inhibition of cytokine synthesis.
We found an increased percent of CD4+CD25varCD69+TGF-β+IL-10+Foxp3− lymphocytes in patients with SLE compared to controls.
In addition, a significant diminution in the suppressive effect of these cells on the activation of autologous T lymphocytes was observed in most patients with SLE.
Accordingly, CD69+ Treg cells from SLE patients showed a defective capability to inhibit the release of IL-2, IL-6, IL-10, and IL-17A by autologous lymphocytes.
Our findings suggest that while CD4+CD69+ Treg lymphocyte levels are increased in SLE patients, these cells are apparently unable to contribute to the downmodulation of the autoimmune response and the tissue damage seen in this condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vitales-Noyola, Marlen& Oceguera-Maldonado, Brenda& Niño-Moreno, Perla& Baltazar-Benítez, Nubia& Baranda, Lourdes& Layseca-Espinosa, Esther…[et al.]. 2017. Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vitales-Noyola, Marlen…[et al.]. Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vitales-Noyola, Marlen& Oceguera-Maldonado, Brenda& Niño-Moreno, Perla& Baltazar-Benítez, Nubia& Baranda, Lourdes& Layseca-Espinosa, Esther…[et al.]. Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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