Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells
Joint Authors
Layseca-Espinosa, Esther
Vitales-Noyola, Marlen
Oceguera-Maldonado, Brenda
Niño-Moreno, Perla
Baltazar-Benítez, Nubia
Abud-Mendoza, Carlos
González-Amaro, Roberto
Baranda, Lourdes
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
T regulatory (Treg) cells have a key role in the pathogenesis of chronic inflammatory and autoimmune diseases.
A CD4+CD69+ T cell subset has been described that behaves as Treg lymphocytes, exerting an important immune suppressive effect.
In this study, we analyzed the levels and function of CD4+CD69+ Treg cells in patients with systemic lupus erythematosus (SLE).
Blood samples were obtained from 22 patients with SLE and 25 healthy subjects.
Levels of CD4+CD69+ Treg cells were analyzed by multiparametric flow cytometry, and their function was measured by an assay of suppression of lymphocyte activation and through the inhibition of cytokine synthesis.
We found an increased percent of CD4+CD25varCD69+TGF-β+IL-10+Foxp3− lymphocytes in patients with SLE compared to controls.
In addition, a significant diminution in the suppressive effect of these cells on the activation of autologous T lymphocytes was observed in most patients with SLE.
Accordingly, CD69+ Treg cells from SLE patients showed a defective capability to inhibit the release of IL-2, IL-6, IL-10, and IL-17A by autologous lymphocytes.
Our findings suggest that while CD4+CD69+ Treg lymphocyte levels are increased in SLE patients, these cells are apparently unable to contribute to the downmodulation of the autoimmune response and the tissue damage seen in this condition.
American Psychological Association (APA)
Vitales-Noyola, Marlen& Oceguera-Maldonado, Brenda& Niño-Moreno, Perla& Baltazar-Benítez, Nubia& Baranda, Lourdes& Layseca-Espinosa, Esther…[et al.]. 2017. Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188163
Modern Language Association (MLA)
Vitales-Noyola, Marlen…[et al.]. Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188163
American Medical Association (AMA)
Vitales-Noyola, Marlen& Oceguera-Maldonado, Brenda& Niño-Moreno, Perla& Baltazar-Benítez, Nubia& Baranda, Lourdes& Layseca-Espinosa, Esther…[et al.]. Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188163