Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro
المؤلفون المشاركون
Chowdhury, Imran H.
Narra, Hema P.
Sahni, Abha
Khanipov, Kamil
Schroeder, Casey L. C.
Patel, Jignesh
Fofanov, Yuriy
Sahni, Sanjeev K.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-25
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Endothelial cell interactions with lipopolysaccharide (LPS) involve both activating and repressing signals resulting in pronounced alterations in their transcriptome and proteome.
Noncoding RNAs are now appreciated as posttranscriptional and translational regulators of cellular signaling and responses, but their expression status and roles during endothelial interactions with LPS are not well understood.
We report on the expression profile of long noncoding (lnc) RNAs of human microvascular endothelial cells in response to LPS.
We have identified a total of 10,781 and 8310 lncRNA transcripts displaying either positive or negative regulation of expression, respectively, at 3 and 24 h posttreatment.
A majority of LPS-induced lncRNAs are multiexonic and distributed across the genome as evidenced by their presence on all chromosomes.
Present among these are a total of 44 lncRNAs with known regulatory functions, of which 41 multiexonic lncRNAs have multiple splice variants.
We have further validated splice variant-specific expression of EGO (NONHSAT087634) and HOTAIRM1 (NONHSAT119666) at 3 h and significant upregulation of lnc-IL7R at 24 h.
This study illustrates the genome-wide regulation of endothelial lncRNA splice variants in response to LPS and provides a foundation for further investigations of differentially expressed lncRNA transcripts in endothelial responses to LPS and pathophysiology of sepsis/septic shock.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chowdhury, Imran H.& Narra, Hema P.& Sahni, Abha& Khanipov, Kamil& Schroeder, Casey L. C.& Patel, Jignesh…[et al.]. 2017. Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1188247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chowdhury, Imran H.…[et al.]. Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro. Mediators of Inflammation No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1188247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chowdhury, Imran H.& Narra, Hema P.& Sahni, Abha& Khanipov, Kamil& Schroeder, Casey L. C.& Patel, Jignesh…[et al.]. Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1188247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر