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Dual Roles of IL-27 in Cancer Biology and Immunotherapy
المؤلفون المشاركون
Fabbi, Marina
Carbotti, Grazia
Ferrini, Silvano
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-01
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families.
IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, which mediate signaling predominantly through STAT1 and STAT3.
IL-27 was initially reported as an immune-enhancing cytokine that supports CD4+ T cell proliferation, T helper (Th)1 cell differentiation, and IFN-γ production, acting in concert with IL-12.
However, subsequent studies demonstrated that IL-27 displays complex immune-regulatory functions, which may result in either proinflammatory or anti-inflammatory effects in relationship to the biological context and experimental models considered.
Several pieces of evidence, obtained in preclinical tumor models, indicated that IL-27 has a potent antitumor activity, related not only to the induction of tumor-specific Th1 and cytotoxic T lymphocyte (CTL) responses but also to direct inhibitory effects on tumor cell proliferation, survival, invasiveness, and angiogenic potential.
Nonetheless, given its immune-regulatory functions, the effects of IL-27 on cancer may be dual and protumor effects may also occur.
Here, we will summarize IL-27 biological activities and its functional overlaps with the IFNs and discuss its dual role in tumors in the light of potential applications to cancer immunotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fabbi, Marina& Carbotti, Grazia& Ferrini, Silvano. 2017. Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fabbi, Marina…[et al.]. Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fabbi, Marina& Carbotti, Grazia& Ferrini, Silvano. Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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