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Dual Roles of IL-27 in Cancer Biology and Immunotherapy
Joint Authors
Fabbi, Marina
Carbotti, Grazia
Ferrini, Silvano
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families.
IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, which mediate signaling predominantly through STAT1 and STAT3.
IL-27 was initially reported as an immune-enhancing cytokine that supports CD4+ T cell proliferation, T helper (Th)1 cell differentiation, and IFN-γ production, acting in concert with IL-12.
However, subsequent studies demonstrated that IL-27 displays complex immune-regulatory functions, which may result in either proinflammatory or anti-inflammatory effects in relationship to the biological context and experimental models considered.
Several pieces of evidence, obtained in preclinical tumor models, indicated that IL-27 has a potent antitumor activity, related not only to the induction of tumor-specific Th1 and cytotoxic T lymphocyte (CTL) responses but also to direct inhibitory effects on tumor cell proliferation, survival, invasiveness, and angiogenic potential.
Nonetheless, given its immune-regulatory functions, the effects of IL-27 on cancer may be dual and protumor effects may also occur.
Here, we will summarize IL-27 biological activities and its functional overlaps with the IFNs and discuss its dual role in tumors in the light of potential applications to cancer immunotherapy.
American Psychological Association (APA)
Fabbi, Marina& Carbotti, Grazia& Ferrini, Silvano. 2017. Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188312
Modern Language Association (MLA)
Fabbi, Marina…[et al.]. Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188312
American Medical Association (AMA)
Fabbi, Marina& Carbotti, Grazia& Ferrini, Silvano. Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188312