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The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples
المؤلفون المشاركون
Harlid, Sophia
Myte, Robin
Van Guelpen, Bethany
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Metabolic syndrome (MetS), a set of metabolic risk factors including obesity, dysglycemia, and dyslipidemia, is associated with increased colorectal cancer (CRC) risk.
A putative biological mechanism is chronic, low-grade inflammation, both a feature of MetS and a CRC risk factor.
However, excess body fat also induces a proinflammatory state and increases CRC risk.
In order to explore the relationship between MetS, body size, inflammation, and CRC, we studied large panels of inflammatory and cancer biomarkers.
We included 138 participants from the Västerbotten Intervention Programme with repeated sampling occasions, 10 years apart.
Plasma samples were analyzed for 178 protein markers by proximity extension assay.
To identify associations between plasma protein levels and MetS components, linear mixed models were fitted for each protein.
Twelve proteins were associated with at least one MetS component, six of which were associated with MetS score.
MetS alone was not related to any protein.
Instead, BMI displayed by far the strongest associations with the biomarkers.
One of the 12 MetS score-related proteins (FGF-21), also associated with BMI, was associated with an increased CRC risk (OR 1.71, 95% CI 1.19–2.47).
We conclude that overweight and obesity, acting through both inflammation and other mechanisms, likely explain the MetS-CRC connection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Harlid, Sophia& Myte, Robin& Van Guelpen, Bethany. 2017. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188349
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Harlid, Sophia…[et al.]. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188349
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Harlid, Sophia& Myte, Robin& Van Guelpen, Bethany. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188349
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188349
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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