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The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples
Joint Authors
Harlid, Sophia
Myte, Robin
Van Guelpen, Bethany
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Metabolic syndrome (MetS), a set of metabolic risk factors including obesity, dysglycemia, and dyslipidemia, is associated with increased colorectal cancer (CRC) risk.
A putative biological mechanism is chronic, low-grade inflammation, both a feature of MetS and a CRC risk factor.
However, excess body fat also induces a proinflammatory state and increases CRC risk.
In order to explore the relationship between MetS, body size, inflammation, and CRC, we studied large panels of inflammatory and cancer biomarkers.
We included 138 participants from the Västerbotten Intervention Programme with repeated sampling occasions, 10 years apart.
Plasma samples were analyzed for 178 protein markers by proximity extension assay.
To identify associations between plasma protein levels and MetS components, linear mixed models were fitted for each protein.
Twelve proteins were associated with at least one MetS component, six of which were associated with MetS score.
MetS alone was not related to any protein.
Instead, BMI displayed by far the strongest associations with the biomarkers.
One of the 12 MetS score-related proteins (FGF-21), also associated with BMI, was associated with an increased CRC risk (OR 1.71, 95% CI 1.19–2.47).
We conclude that overweight and obesity, acting through both inflammation and other mechanisms, likely explain the MetS-CRC connection.
American Psychological Association (APA)
Harlid, Sophia& Myte, Robin& Van Guelpen, Bethany. 2017. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188349
Modern Language Association (MLA)
Harlid, Sophia…[et al.]. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188349
American Medical Association (AMA)
Harlid, Sophia& Myte, Robin& Van Guelpen, Bethany. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188349