Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection
المؤلفون المشاركون
Azeredo, Elzinandes Leal de
de-Oliveira Pinto, Luzia Maria
Gandini, Mariana
Petitinga-Paiva, Fabienne
Marinho, Cíntia Ferreira
Correa, Gladys
Souza, Luiz José de
Cunha, Rivaldo Venâncio
Kubelka, Claire Fernandes
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal.
NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis.
We investigated NK cell involvement during dengue infection.
A higher frequency of NK cell subsets and TRAIL+NK cells was found in mild DF cases when compared to that in severe cases or healthy donors.
NK activation markers such as CD107a and TLR3 were upregulated in patients’ cells compared to those in healthy donors.
In addition, IL12 related to NK cell activation were upregulated in mild DF cases.
In vitro PBMC culture models show that DENV-stimulated and IFNα-stimulated NK cells were able to express TRAIL, suggesting an indirect activation of cells, regarding TRAIL expression.
Type I IFN receptor blockage on DENV-stimulated PBMCs showed TRAIL expression on NK cells is partially IFNα dependent.
In addition, during PBMC stimulation, TRAIL expression on NK cells was inversely correlated with DENV-positive monocytes.
Therefore, we observed DENV-induced activation of NK cell populations.
A higher activation of NK cells would promote limited viral spread, resulting in decreased inflammatory response, contributing to protection against dengue severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gandini, Mariana& Petitinga-Paiva, Fabienne& Marinho, Cíntia Ferreira& Correa, Gladys& de-Oliveira Pinto, Luzia Maria& Souza, Luiz José de…[et al.]. 2017. Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188471
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gandini, Mariana…[et al.]. Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188471
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gandini, Mariana& Petitinga-Paiva, Fabienne& Marinho, Cíntia Ferreira& Correa, Gladys& de-Oliveira Pinto, Luzia Maria& Souza, Luiz José de…[et al.]. Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188471
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188471
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر