Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection
Joint Authors
Azeredo, Elzinandes Leal de
de-Oliveira Pinto, Luzia Maria
Gandini, Mariana
Petitinga-Paiva, Fabienne
Marinho, Cíntia Ferreira
Correa, Gladys
Souza, Luiz José de
Cunha, Rivaldo Venâncio
Kubelka, Claire Fernandes
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal.
NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis.
We investigated NK cell involvement during dengue infection.
A higher frequency of NK cell subsets and TRAIL+NK cells was found in mild DF cases when compared to that in severe cases or healthy donors.
NK activation markers such as CD107a and TLR3 were upregulated in patients’ cells compared to those in healthy donors.
In addition, IL12 related to NK cell activation were upregulated in mild DF cases.
In vitro PBMC culture models show that DENV-stimulated and IFNα-stimulated NK cells were able to express TRAIL, suggesting an indirect activation of cells, regarding TRAIL expression.
Type I IFN receptor blockage on DENV-stimulated PBMCs showed TRAIL expression on NK cells is partially IFNα dependent.
In addition, during PBMC stimulation, TRAIL expression on NK cells was inversely correlated with DENV-positive monocytes.
Therefore, we observed DENV-induced activation of NK cell populations.
A higher activation of NK cells would promote limited viral spread, resulting in decreased inflammatory response, contributing to protection against dengue severity.
American Psychological Association (APA)
Gandini, Mariana& Petitinga-Paiva, Fabienne& Marinho, Cíntia Ferreira& Correa, Gladys& de-Oliveira Pinto, Luzia Maria& Souza, Luiz José de…[et al.]. 2017. Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188471
Modern Language Association (MLA)
Gandini, Mariana…[et al.]. Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188471
American Medical Association (AMA)
Gandini, Mariana& Petitinga-Paiva, Fabienne& Marinho, Cíntia Ferreira& Correa, Gladys& de-Oliveira Pinto, Luzia Maria& Souza, Luiz José de…[et al.]. Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188471