![](/images/graphics-bg.png)
Platelet-Released Growth Factors Induce Differentiation of Primary Keratinocytes
المؤلفون المشاركون
Pufe, T.
Lippross, Sebastian
Tohidnezhad, Mersedeh
Jahr, Holger
Cremer, Jochen
Bayer, Andreas
Lammel, Justus
Behrendt, Peter
Klüter, Tim
Rademacher, Franziska
Gläser, Regine
Harder, Jürgen
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Autologous thrombocyte concentrate lysates, for example, platelet-released growth factors, (PRGFs) or their clinically related formulations (e.g., Vivostat PRF®) came recently into the physicians’ focus as they revealed promising effects in regenerative and reparative medicine such as the support of healing of chronic wounds.
To elucidate the underlying mechanisms, we analyzed the influence of PRGF and Vivostat PRF on human keratinocyte differentiation in vitro and on epidermal differentiation status of skin wounds in vivo.
Therefore, we investigated the expression of early (keratin 1 and keratin 10) and late (transglutaminase-1 and involucrin) differentiation markers.
PRGF treatment of primary human keratinocytes decreased keratin 1 and keratin 10 gene expression but induced involucrin and transglutaminase-1 gene expression in an epidermal growth factor receptor- (EGFR-) dependent manner.
In concordance with these results, microscopic analyses revealed that PRGF-treated human keratinocytes displayed morphological features typical of keratinocytes undergoing terminal differentiation.
In vivo treatment of artificial human wounds with Vivostat PRF revealed a significant induction of involucrin and transglutaminase-1 gene expression.
Together, our results indicate that PRGF and Vivostat PRF induce terminal differentiation of primary human keratinocytes.
This potential mechanism may contribute to the observed beneficial effects in the treatment of hard-to-heal wounds with autologous thrombocyte concentrate lysates in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bayer, Andreas& Tohidnezhad, Mersedeh& Lammel, Justus& Lippross, Sebastian& Behrendt, Peter& Klüter, Tim…[et al.]. 2017. Platelet-Released Growth Factors Induce Differentiation of Primary Keratinocytes. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bayer, Andreas…[et al.]. Platelet-Released Growth Factors Induce Differentiation of Primary Keratinocytes. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bayer, Andreas& Tohidnezhad, Mersedeh& Lammel, Justus& Lippross, Sebastian& Behrendt, Peter& Klüter, Tim…[et al.]. Platelet-Released Growth Factors Induce Differentiation of Primary Keratinocytes. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)