![](/images/graphics-bg.png)
High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management
المؤلفون المشاركون
Xiao, Zhengwen
Ball, Chad G.
Malig, Michelle S.
Jenne, Craig N.
Roberts, Derek J.
Kirkpatrick, Andrew. W.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Previous studies assessing various cytokines in the critically ill/injured have been uninformative in terms of translating to clinical care management.
Animal abdominal sepsis work suggests that enhanced intraperitoneal (IP) clearance of Damage-Associated Molecular Patterns (DAMPs) improves outcome.
Thus measuring the responses of DAMPs offers alternate potential insights and a representative DAMP, High Mobility Group Box-1 protein (HMGB-1), was considered.
While IP biomediators are being recognized in critical illness/trauma, HMGB-1 behaviour has not been examined in open abdomen (OA) management.
Methods.
A modified protocol for HMGB-1 detection was used to examine plasma/IP fluid samples from 44 critically ill/injured OA patients enrolled in a randomized controlled trial comparing two negative pressure peritoneal therapies (NPPT): Active NPPT (ANPPT) and Barker’s Vacuum Pack NPPT (BVP).
Samples were collected and analyzed at the time of laparotomy and at 24 and 48 hours after.
Results.
There were no statistically significant differences in survivor versus nonsurvivor HMGB-1 plasma or IP concentrations at baseline, 24 hours, or 48 hours.
However, plasma HMGB-1 levels tended to increase continuously in the BVP cohort.
Conclusions.
HMGB-1 appeared to behave differently between NPPT cohorts.
Further studies are needed to elucidate the relationship of HMGB-1 and outcomes in septic/injured patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malig, Michelle S.& Jenne, Craig N.& Ball, Chad G.& Roberts, Derek J.& Xiao, Zhengwen& Kirkpatrick, Andrew. W.. 2017. High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188537
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malig, Michelle S.…[et al.]. High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188537
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malig, Michelle S.& Jenne, Craig N.& Ball, Chad G.& Roberts, Derek J.& Xiao, Zhengwen& Kirkpatrick, Andrew. W.. High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188537
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188537
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)