High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management
Joint Authors
Xiao, Zhengwen
Ball, Chad G.
Malig, Michelle S.
Jenne, Craig N.
Roberts, Derek J.
Kirkpatrick, Andrew. W.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Previous studies assessing various cytokines in the critically ill/injured have been uninformative in terms of translating to clinical care management.
Animal abdominal sepsis work suggests that enhanced intraperitoneal (IP) clearance of Damage-Associated Molecular Patterns (DAMPs) improves outcome.
Thus measuring the responses of DAMPs offers alternate potential insights and a representative DAMP, High Mobility Group Box-1 protein (HMGB-1), was considered.
While IP biomediators are being recognized in critical illness/trauma, HMGB-1 behaviour has not been examined in open abdomen (OA) management.
Methods.
A modified protocol for HMGB-1 detection was used to examine plasma/IP fluid samples from 44 critically ill/injured OA patients enrolled in a randomized controlled trial comparing two negative pressure peritoneal therapies (NPPT): Active NPPT (ANPPT) and Barker’s Vacuum Pack NPPT (BVP).
Samples were collected and analyzed at the time of laparotomy and at 24 and 48 hours after.
Results.
There were no statistically significant differences in survivor versus nonsurvivor HMGB-1 plasma or IP concentrations at baseline, 24 hours, or 48 hours.
However, plasma HMGB-1 levels tended to increase continuously in the BVP cohort.
Conclusions.
HMGB-1 appeared to behave differently between NPPT cohorts.
Further studies are needed to elucidate the relationship of HMGB-1 and outcomes in septic/injured patients.
American Psychological Association (APA)
Malig, Michelle S.& Jenne, Craig N.& Ball, Chad G.& Roberts, Derek J.& Xiao, Zhengwen& Kirkpatrick, Andrew. W.. 2017. High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188537
Modern Language Association (MLA)
Malig, Michelle S.…[et al.]. High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188537
American Medical Association (AMA)
Malig, Michelle S.& Jenne, Craig N.& Ball, Chad G.& Roberts, Derek J.& Xiao, Zhengwen& Kirkpatrick, Andrew. W.. High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188537