Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation
المؤلفون المشاركون
Wang, Ning
Zhu, Yuanfeng
Fan, Shijun
Liu, Wancheng
Yang, Xuejiao
Zheng, Xinchuan
Li, Yan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A growing body of literature suggests that most chronic autoimmune diseases are associated with inappropriate inflammation mediated by Toll-like receptor (TLR) 3, TLR7/8, or TLR9.
Therefore, research into blocking TLR activation to treat these disorders has become a hot topic.
Here, we report the immunomodulatory properties of a nonstimulatory CpG-containing oligodeoxynucleotide (CpG-ODN), CpG-c41, which had previously only been known as a TLR9 antagonist.
In this study, we found that both in vitro and in vivo CpG-c41 decreased levels of various proinflammatory factors that were induced by single activation or coactivation of intracellular TLRs, but not membrane-bound TLRs, no matter what downstream signal pathways the TLRs depend on.
Moreover, CpG-c41 attenuated excessive inflammation in the imiquimod-induced psoriasis-like mouse model of skin inflammation by suppressing immune cell infiltration and release of inflammatory factors.
We also found evidence that the immunosuppressive effects of CpG-c41 on other intracellular TLRs are mediated by a TLR9-independent mechanism.
These results suggest that CpG-c41 acts as an upstream of signaling cascades, perhaps on the processes of ligand internalization and transfer.
Taken together, these results suggest that CpG-c41 disrupts various aspects of intracellular TLR activation and provides a deeper insight into the regulation of innate immunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Wancheng& Yang, Xuejiao& Wang, Ning& Fan, Shijun& Zhu, Yuanfeng& Zheng, Xinchuan…[et al.]. 2017. Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188555
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Wancheng…[et al.]. Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188555
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Wancheng& Yang, Xuejiao& Wang, Ning& Fan, Shijun& Zhu, Yuanfeng& Zheng, Xinchuan…[et al.]. Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188555
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188555
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر