Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation
Joint Authors
Wang, Ning
Zhu, Yuanfeng
Fan, Shijun
Liu, Wancheng
Yang, Xuejiao
Zheng, Xinchuan
Li, Yan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A growing body of literature suggests that most chronic autoimmune diseases are associated with inappropriate inflammation mediated by Toll-like receptor (TLR) 3, TLR7/8, or TLR9.
Therefore, research into blocking TLR activation to treat these disorders has become a hot topic.
Here, we report the immunomodulatory properties of a nonstimulatory CpG-containing oligodeoxynucleotide (CpG-ODN), CpG-c41, which had previously only been known as a TLR9 antagonist.
In this study, we found that both in vitro and in vivo CpG-c41 decreased levels of various proinflammatory factors that were induced by single activation or coactivation of intracellular TLRs, but not membrane-bound TLRs, no matter what downstream signal pathways the TLRs depend on.
Moreover, CpG-c41 attenuated excessive inflammation in the imiquimod-induced psoriasis-like mouse model of skin inflammation by suppressing immune cell infiltration and release of inflammatory factors.
We also found evidence that the immunosuppressive effects of CpG-c41 on other intracellular TLRs are mediated by a TLR9-independent mechanism.
These results suggest that CpG-c41 acts as an upstream of signaling cascades, perhaps on the processes of ligand internalization and transfer.
Taken together, these results suggest that CpG-c41 disrupts various aspects of intracellular TLR activation and provides a deeper insight into the regulation of innate immunity.
American Psychological Association (APA)
Liu, Wancheng& Yang, Xuejiao& Wang, Ning& Fan, Shijun& Zhu, Yuanfeng& Zheng, Xinchuan…[et al.]. 2017. Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188555
Modern Language Association (MLA)
Liu, Wancheng…[et al.]. Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188555
American Medical Association (AMA)
Liu, Wancheng& Yang, Xuejiao& Wang, Ning& Fan, Shijun& Zhu, Yuanfeng& Zheng, Xinchuan…[et al.]. Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188555