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HIV as a Cause of Immune Activation and Immunosenescence
المؤلفون المشاركون
Rossouw, Theresa M.
Sokoya, T.
Nieuwoudt, M.
Steel, Helen C.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-25
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Systemic immune activation has emerged as an essential component of the immunopathogenesis of HIV.
It not only leads to faster disease progression, but also to accelerated decline of overall immune competence.
HIV-associated immune activation is characterized by an increase in proinflammatory mediators, dysfunctional T regulatory cells, and a pattern of T-cell-senescent phenotypes similar to those seen in the elderly.
These changes predispose HIV-infected persons to comorbid conditions that have been linked to immunosenescence and inflamm-ageing, such as atherosclerosis and cardiovascular disease, neurodegeneration, and cancer.
In the antiretroviral treatment era, development of such non-AIDS-defining, age-related comorbidities is a major cause of morbidity and mortality.
Treatment strategies aimed at curtailing persistent immune activation and inflammation may help prevent the development of these conditions.
At present, the most effective strategy appears to be early antiretroviral treatment initiation.
No other treatment interventions have been found effective in large-scale clinical trials, and no adjunctive treatment is currently recommended in international HIV treatment guidelines.
This article reviews the role of systemic immune activation in the immunopathogenesis of HIV infection, its causes and the clinical implications linked to immunosenescence in adults, and the therapeutic interventions that have been investigated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sokoya, T.& Steel, Helen C.& Nieuwoudt, M.& Rossouw, Theresa M.. 2017. HIV as a Cause of Immune Activation and Immunosenescence. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188608
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sokoya, T.…[et al.]. HIV as a Cause of Immune Activation and Immunosenescence. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188608
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sokoya, T.& Steel, Helen C.& Nieuwoudt, M.& Rossouw, Theresa M.. HIV as a Cause of Immune Activation and Immunosenescence. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188608
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188608
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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