Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor
المؤلفون المشاركون
Dong, Ning
Yao, Yong-Ming
Lu, Zhongqiu
Zhao, Guang-Ju
Hong, Guang-Liang
Zheng, Jia-yi
Bian, Jia-lan
Chen, Long-wang
Yu, Yan
Chandoo, Arvine
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized.
Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity.
The present study was designed to investigate whether Tregs express TAM receptors and the potential role of Gas6-TAM signal in regulating the suppressive function of Tregs.
Methods.
The protein and mRNA levels of TAM receptors were determined by using Western blot, immunofluorescence, flow cytometry, and RT-PCR.
Then, TAM receptors were silenced using targeted siRNA or blocked with specific antibody.
The suppressive function of Tregs was assessed by using a CFSE-based T cell proliferation assay.
Flow cytometry was used to determine the expression of Foxp3 and CTLA4 whereas cytokines secretion levels were measured by ELISA assay.
Results.
Tregs express both Axl and Mertk receptors.
Gas6 increases the suppressive function of Tregs in vitro and in mice.
Both Foxp3 and CTLA-4 expression on Tregs are enhanced after Gas6 stimulation.
Gas6 enhances the suppressive activity of Tregs mainly through Axl receptor.
Conclusion.
Gas6 has a direct effect on the functions of CD4+CD25+Tregs mainly through its interaction with Axl receptor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Guang-Ju& Zheng, Jia-yi& Bian, Jia-lan& Chen, Long-wang& Dong, Ning& Yu, Yan…[et al.]. 2017. Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188612
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Guang-Ju…[et al.]. Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188612
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Guang-Ju& Zheng, Jia-yi& Bian, Jia-lan& Chen, Long-wang& Dong, Ning& Yu, Yan…[et al.]. Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188612
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188612
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر